TiCl4‐Promoted Asymmetric Aldol Reaction of Oxazolidinones and its Sulphur‐Congeners for Natural Product Synthesis
Prateek Bhamboo, Smritilekha Bera, and Dhananjoy MondalNature is incessantly affianced to construct bio-
active and structurally intriguing compounds with magnifi-
cent three-dimensional frameworks in the Universe. The
inadequacy of these naturally occurring precious compounds
prompted several minds of chemists to synthesise them in a
laboratory for a thorough evaluation of their medicinal and
clinical properties via a structure-activity relationship study.
Finding an optimised methodology to synthesise chiral
natural products has always been challenging in synthetic
organic chemistry, particularly the formation of asymmetric
carbon-carbon bonds adhering to the existing stereochemis-
try. In this context, chiral auxiliaries have proven to be
effective tools for inducing chirality during the synthesis of
chiral molecules. In fact, the chiral auxiliary will allow us to
control the synthesis of many enantiomerically pure isomers
in natural product synthesis. In this area, the significant
contribution of the Evans’ chiral auxiliary in TiCl4-mediated
asymmetric aldol reactions to the installation of known
configurations in organic synthetic chemistry motivated us to
compile an exhaustive and systematic summary of the
relevant research findings published in the last two decades.